Journal: Frontiers in Pharmacology
Article Title: Elevated serum polyclonal immunoglobulin free light chains in patients with severe asthma
doi: 10.3389/fphar.2023.1126535
Figure Lengend Snippet: Serum free light chain (FLC) concentrations in persistent severe asthma participants with peripheral blood eosinophil counts > 300/μL (κ, pink dots; λ, pink squares, κ and λ concentration sum, pink diamonds) or ≤ 300/μL (κ, blue dots; λ, blue squares, κ and λ concentration sum, blue diamonds) (A) , serum total IgE concentrations > 100 kU/L (κ, pink dots; λ, pink squares, κ and λ concentration sum, pink diamonds) or ≤ 100 kU/L (κ, blue dots; λ, blue squares, κ and λ concentration sum, blue diamonds) (B) , serum specific IgE > 1 (κ, pink dots; λ, pink squares, κ and λ concentration sum, pink diamonds) or ≤ 1 (κ, blue dots; λ, blue squares, κ and λ concentration sum, blue diamonds) (C) or fractional exhaled nitric oxide (F E NO) > 25 ppb (κ, pink dots; λ, pink squares, κ and λ concentration sum, pink diamonds) or ≤ 25 ppb (κ, blue dots; λ, blue squares, κ and λ concentration sum, blue diamonds) (D) . Mean values with SD are shown. p < 0.05 was considered significant.
Article Snippet: The nephelometric measurement of FLC was performed using monoclonal antibodies in the N Latex κ and λ FLC kit (Siemens Healthcare Diagnostics Products GmbH, Marburg, Germany).
Techniques: Concentration Assay